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showed the relationships between eNAP-2 and several four-disulfide core antiproteases and also the relationships between eNAP-2 and equine cationic peptides exhibiting selective inhibitory activity against subtilisin and proteinase K (later denoted equinins), reported by Pellegrini et al

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Step 3: Extending the dataset with 2D descriptors The purpose of this step is extending the information space of compounds by adding basic topological and physico-chemical information